Version 5.4
Homo sapiens Gene: ADAM22
Summary
InnateDB Gene IDBG-25323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM22
Gene Name ADAM metallopeptidase domain 22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000008277
Encoded Proteins
IDBP-25325
ADAM metallopeptidase domain 22
IDBP-233507
ADAM metallopeptidase domain 22
IDBP-233509
ADAM metallopeptidase domain 22
IDBP-233511
ADAM metallopeptidase domain 22
IDBP-233513
ADAM metallopeptidase domain 22
IDBP-381143
ADAM metallopeptidase domain 22
IDBP-381144
ADAM metallopeptidase domain 22
IDBP-381168
ADAM metallopeptidase domain 22
IDBP-381170
ADAM metallopeptidase domain 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:87934143-88202889
Strand Forward strand
Band q21.12
Transcripts
ENST00000265727 ENSP00000265727
ENST00000398209 ENSP00000381267
ENST00000398204 ENSP00000381262
ENST00000398203 ENSP00000381261
ENST00000398201 ENSP00000381260
ENST00000439864 ENSP00000391334
ENST00000412441 ENSP00000413899
ENST00000426930 ENSP00000396233
ENST00000413139 ENSP00000412085
ENST00000478920
ENST00000476330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007417 central nervous system development
GO:0008344 adult locomotory behavior
GO:0014037 Schwann cell differentiation
GO:0022011 myelination in peripheral nervous system
GO:0042063 gliogenesis
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040537
View Gene Order
ENSBTAG00000007136
Not yet available
Cross-References
SwissProt Q9P0K1
TrEMBL D6W5P7 Q75MS7 Q86UM2 Q9UKK0
UniProt Splice Variant
Entrez Gene 53616
UniGene Hs.610310 Hs.616826 Hs.630308 Hs.730222
RefSeq NM_021722 NM_004194 NM_016351 NM_021721 NM_021723
HUGO HGNC:201
OMIM 603709
CCDS CCDS43608 CCDS43609 CCDS43610 CCDS47637
HPRD 04751
IMGT
EMBL AB009671 AC004992 AC005075 AC005164 AF073291 AF155381 AF155382 AF158637 AF158642 CH471091
GenPept AAD55251 AAD55253 AAF22476 AAF73288 AAF73289 AAP21878 AAS07417 BAA32349 BAA32350 EAW76913 EAW76915 EAW76917 EAW76918
RNA Seq Atlas 53616

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca