InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Med12

Summary

InnateDB Gene

IDBG-253359.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med12

Gene Name

mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)

Synonyms

230kDa; Mopa; OPA-1; Tnrc11; Trap230

Species

Mus musculus

Ensembl Gene

ENSMUSG00000079487

Encoded Proteins

IDBP-163516

mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)

IDBP-163518

mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)

IDBP-400705

mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)

IDBP-400707

mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184634:
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:101274030-101297465

Strand

Forward strand

Band

Transcripts

ENSMUST00000087956	ENSMUSP00000085269
ENSMUST00000087948	ENSMUSP00000085260
ENSMUST00000117706	ENSMUSP00000112852
ENSMUST00000117203	ENSMUSP00000112729
ENSMUST00000156131
ENSMUST00000146877
ENSMUST00000148846
ENSMUST00000132269
ENSMUST00000137664

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0001843	neural tube closure
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007507	heart development
GO:0014003	oligodendrocyte development
GO:0014044	Schwann cell development
GO:0019827	stem cell maintenance
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090245	axis elongation involved in somitogenesis