Version 5.4
Homo sapiens Gene: SRI
Summary
InnateDB Gene IDBG-25472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRI
Gene Name sorcin
Synonyms CP-22; CP22; SCN; V19
Species Homo sapiens
Ensembl Gene ENSG00000075142
Encoded Proteins
IDBP-25474
sorcin
IDBP-241167
sorcin
IDBP-381178
sorcin
IDBP-381181
sorcin
IDBP-381183
sorcin
IDBP-482529
sorcin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:88205118-88226993
Strand Reverse strand
Band q21.12
Transcripts
ENST00000265729 ENSP00000265729
ENST00000394641 ENSP00000378137
ENST00000419179 ENSP00000397609
ENST00000431660 ENSP00000391148
ENST00000457606 ENSP00000415271
ENST00000472930
ENST00000490437 ENSP00000418512
ENST00000486860
ENST00000488015
ENST00000489079
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 29 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005102 receptor binding
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044325 ion channel binding
GO:0046982 protein heterodimerization activity
GO:0070491 repressing transcription factor binding
Biological Process
GO:0001508 action potential
GO:0006508 proteolysis
GO:0006810 transport
GO:0006816 calcium ion transport
GO:0006880 intracellular sequestering of iron ion
GO:0006942 regulation of striated muscle contraction
GO:0007165 signal transduction
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0008016 regulation of heart contraction
GO:0010459 negative regulation of heart rate
GO:0010649 regulation of cell communication by electrical coupling
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051924 regulation of calcium ion transport
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004 regulation of cardiac muscle cell contraction
GO:1901077 regulation of relaxation of muscle
GO:1901841 regulation of high voltage-gated calcium channel activity
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:2000678 negative regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0030424 axon
GO:0031982 vesicle
GO:0033017 sarcoplasmic reticulum membrane
GO:0042584 chromaffin granule membrane
GO:0043679 axon terminus
GO:0044326 dendritic spine neck
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003161
View Gene Order
ENSBTAG00000010390
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P30626
TrEMBL B4DHQ6 C9J0K6 E9PG82 Q75MZ6
UniProt Splice Variant
Entrez Gene 6717
UniGene Hs.489040 Hs.706466
RefSeq NM_001256891 NM_001256892 NM_003130 NM_198901 XM_006716097
HUGO HGNC:11292
OMIM 182520
CCDS CCDS47638 CCDS5612 CCDS59063
HPRD
IMGT
EMBL AC003991 AC005075 AK295225 AK296601 BC011025 BM739144 CH471091 L12387 M32886
GenPept AAA60588 AAA92155 AAB96327 AAH11025 BAG58218 BAG59214 EAW76909 EAW76910
RNA Seq Atlas 6717

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca