Version 5.4
Homo sapiens Gene: SNTG2
Summary
InnateDB Gene IDBG-25486.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNTG2
Gene Name syntrophin, gamma 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172554
Encoded Proteins
IDBP-25488
syntrophin, gamma 2
IDBP-292637
syntrophin, gamma 2
IDBP-361726
syntrophin, gamma 2
IDBP-361727
syntrophin, gamma 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy. There is evidence of alternative splicing yet the full-length nature of these variants has not been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:950868-1367613
Strand Forward strand
Band p25.3
Transcripts
ENST00000308624 ENSP00000311837
ENST00000407292 ENSP00000385020
ENST00000450962 ENSP00000401997
ENST00000452177 ENSP00000412249
ENST00000463442
ENST00000475201
ENST00000467759
ENST00000494178
ENST00000498321
ENST00000489646
ENST00000471239
ENST00000472606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0007417 central nervous system development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016013 syntrophin complex
GO:0042383 sarcolemma
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020672
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595069
RefSeq NM_018968 XM_006711888 XM_006711890
HUGO
OMIM
CCDS CCDS46220
HPRD 16374
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca