InnateDB: Systems Biology of the Innate Immune Response

The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:30053090-30070457

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000338110	ENSP00000336927
ENST00000395248	ENSP00000378669
ENST00000395240	ENSP00000378661
ENST00000412304	ENSP00000400452
ENST00000562679	ENSP00000455455
ENST00000566146
ENST00000569798	ENSP00000455857
ENST00000569545	ENSP00000455700
ENST00000568435	ENSP00000457683
ENST00000562302
ENST00000562168	ENSP00000456020
ENST00000564546	ENSP00000455917
ENST00000565355	ENSP00000456098
ENST00000567249
ENST00000562240
ENST00000564595	ENSP00000457468
ENST00000566846	ENSP00000454499
ENST00000564688	ENSP00000457514
ENST00000563987	ENSP00000457643
ENST00000567555
ENST00000564521
ENST00000566012
ENST00000566130
ENST00000566280
ENST00000563060	ENSP00000455800
ENST00000575627
ENST00000566897	ENSP00000455724

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004332	fructose-bisphosphate aldolase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0015631	tubulin binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0070061	fructose binding

Biological Process

GO:0002576	platelet degranulation
GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006754	ATP biosynthetic process
GO:0006941	striated muscle contraction
GO:0007015	actin filament organization
GO:0007596	blood coagulation
GO:0008360	regulation of cell shape
GO:0030168	platelet activation
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046716	muscle cell cellular homeostasis
GO:0051289	protein homotetramerization

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0031093	platelet alpha granule lumen
GO:0031430	M band
GO:0031674	I band
GO:0070062	extracellular vesicular exosome