Version 5.4
Homo sapiens Gene: TPO
Summary
InnateDB Gene IDBG-25524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPO
Gene Name thyroid peroxidase
Synonyms MSA; TDH2A; TPX
Species Homo sapiens
Ensembl Gene ENSG00000115705
Encoded Proteins
IDBP-25526
thyroid peroxidase
IDBP-25528
thyroid peroxidase
IDBP-25532
thyroid peroxidase
IDBP-25534
thyroid peroxidase
IDBP-25542
thyroid peroxidase
IDBP-25544
thyroid peroxidase
IDBP-361824
thyroid peroxidase
IDBP-361829
thyroid peroxidase
IDBP-361837
thyroid peroxidase
IDBP-361840
thyroid peroxidase
IDBP-476210
thyroid peroxidase
IDBP-596527
thyroid peroxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:1374223-1543711
Strand Forward strand
Band p25.3
Transcripts
ENST00000382269 ENSP00000371704
ENST00000329066 ENSP00000329869
ENST00000346956 ENSP00000263886
ENST00000345913 ENSP00000318820
ENST00000382201 ENSP00000371636
ENST00000382198 ENSP00000371633
ENST00000423320 ENSP00000390994
ENST00000422464 ENSP00000405788
ENST00000446278 ENSP00000400033
ENST00000425083 ENSP00000389659
ENST00000497517
ENST00000469607 ENSP00000419461
ENST00000462973
ENST00000479902
ENST00000539820 ENSP00000444840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004447 iodide peroxidase activity
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0020037 heme binding
Biological Process
GO:0006590 thyroid hormone generation
GO:0006979 response to oxidative stress
GO:0034641 cellular nitrogen compound metabolic process
GO:0035162 embryonic hemopoiesis
GO:0042446 hormone biosynthetic process
GO:0042744 hydrogen peroxide catabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020673
View Gene Order
Pathways
NETPATH
REACTOME
REACT_15292
Thyroxine biosynthesis pathway
REACT_15513
Amine-derived hormones pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa00350
Tyrosine metabolism pathway
hsa05320
Autoimmune thyroid disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467554 Hs.598371 Hs.735569
RefSeq NM_000547 NM_001206744 NM_001206745 NM_175719 NM_175721 NM_175722 XM_005264699 XM_005264701 XM_005264702
HUGO
OMIM
CCDS CCDS1643 CCDS1644 CCDS1646
HPRD 06000
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca