Version 5.4
Homo sapiens Gene: STEAP1
Summary
InnateDB Gene IDBG-25614.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STEAP1
Gene Name six transmembrane epithelial antigen of the prostate 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164647
Encoded Proteins
IDBP-25616
six transmembrane epithelial antigen of the prostate 1
IDBP-381225
six transmembrane epithelial antigen of the prostate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:90154375-90164829
Strand Forward strand
Band q21.13
Transcripts
ENST00000297205 ENSP00000297205
ENST00000412573 ENSP00000394402
ENST00000475789
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015267 channel activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 ion transport
GO:0055072 iron ion homeostasis
GO:0055085 transmembrane transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0010008 endosome membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015652
View Gene Order
ENSBTAG00000015749
Not yet available
Cross-References
SwissProt Q9UHE8
TrEMBL
UniProt Splice Variant
Entrez Gene 26872
UniGene
RefSeq NM_012449
HUGO HGNC:11378
OMIM 604415
CCDS CCDS5614
HPRD 05106
IMGT
EMBL AC004969 AC005053 AF186249 BC011802 CH236949
GenPept AAD15620 AAF17479 AAH11802 EAL24167
RNA Seq Atlas 26872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca