Homo sapiens Gene: STEAP2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-25663.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | STEAP2 | ||||||||||||||||||
Gene Name | STEAP family member 2, metalloreductase | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000157214 | ||||||||||||||||||
Encoded Proteins |
STEAP family member 2, metalloreductase
STEAP family member 2, metalloreductase
STEAP family member 2, metalloreductase
STEAP family member 2, metalloreductase
STEAP family member 2, metalloreductase
STEAP family member 2, metalloreductase
STEAP family member 2, metalloreductase
STEAP family member 2, metalloreductase
STEAP family member 2, metalloreductase
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 7:90167590-90238137 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q21.13 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Transferrin endocytosis and recycling pathway
Iron uptake and transport pathway
Transmembrane transport of small molecules pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.489051 Hs.622277 Hs.633629 | ||||||||||||||||||
RefSeq | NM_001040665 NM_001040666 NM_001244944 NM_001244945 NM_001244946 NM_152999 XM_006715921 XM_006715922 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS43612 CCDS5615 CCDS59064 | ||||||||||||||||||
HPRD | 05481 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||