Version 5.4
Homo sapiens Gene: ARNT2
Summary
InnateDB Gene IDBG-25737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARNT2
Gene Name aryl-hydrocarbon receptor nuclear translocator 2
Synonyms bHLHe1; WEDAS
Species Homo sapiens
Ensembl Gene ENSG00000172379
Encoded Proteins
IDBP-25739
aryl-hydrocarbon receptor nuclear translocator 2
IDBP-586252
aryl-hydrocarbon receptor nuclear translocator 2
IDBP-590025
aryl-hydrocarbon receptor nuclear translocator 2
IDBP-592497
aryl-hydrocarbon receptor nuclear translocator 2
IDBP-813560
aryl-hydrocarbon receptor nuclear translocator 2
IDBP-813562
aryl-hydrocarbon receptor nuclear translocator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Jul 2008]
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:80404350-80597937
Strand Forward strand
Band q25.1
Transcripts
ENST00000303329 ENSP00000307479
ENST00000529181
ENST00000533983 ENSP00000453651
ENST00000527771 ENSP00000453792
ENST00000525103 ENSP00000452961
ENST00000531595
ENST00000558849
ENST00000525505
ENST00000622346 ENSP00000479393
ENST00000610490 ENSP00000483762
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
Experimentally validated
Total 63 [view]
Protein-Protein 62 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0017162 aryl hydrocarbon receptor binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0032355 response to estradiol
GO:0043066 negative regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015709
View Gene Order
ENSBTAG00000012351
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05211
Renal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt Q9HBZ2
TrEMBL H0YKW1
UniProt Splice Variant
Entrez Gene 9915
UniGene Hs.459070 Hs.610210
RefSeq NM_014862
HUGO HGNC:16876
OMIM 606036
CCDS CCDS32307
HPRD
IMGT
EMBL AB002305 AC016705 AC108451 AF185593 AF185594 AF185595 AF185596 AF185597 AF185598 AF185599 AF185600 AF185601 AF185602 AF185603 AF185604 AF185605 AF185606 AF185607 AF185608 AF185609 AF185610 AK295763 BC036099 BX647212 CH471136
GenPept AAG15310 AAH36099 BAA20766 BAG58589 EAW99114
RNA Seq Atlas 9915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca