Version 5.4
Homo sapiens Gene: SENP3
Summary
InnateDB Gene IDBG-25742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP3
Gene Name SUMO1/sentrin/SMT3 specific peptidase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161956
Encoded Proteins
IDBP-25744
SUMO1/sentrin/SMT3 specific peptidase 3
IDBP-365860
SUMO1/sentrin/SMT3 specific peptidase 3
IDBP-763294
IDBP-760167
IDBP-763534
IDBP-806636
SUMO1/sentrin/SMT3 specific peptidase 3
IDBP-806639
SUMO1/sentrin/SMT3 specific peptidase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7561875-7571969
Strand Forward strand
Band p13.1
Transcripts
ENST00000321337 ENSP00000314029
ENST00000429205 ENSP00000403712
ENST00000582789 ENSP00000464172
ENST00000581010
ENST00000581093 ENSP00000462461
ENST00000580997
ENST00000580231 ENSP00000463358
ENST00000583277
ENST00000619785 ENSP00000482398
ENST00000610454 ENSP00000479187
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 57 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005204
View Gene Order
ENSBTAG00000000131
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 26168
UniGene
RefSeq NM_015670
HUGO HGNC:17862
OMIM 612844
CCDS CCDS73958
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 26168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca