Version 5.4
Homo sapiens Gene: TCEB1
Summary
InnateDB Gene IDBG-25766.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCEB1
Gene Name transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
Synonyms eloC; SIII
Species Homo sapiens
Ensembl Gene ENSG00000154582
Encoded Proteins
IDBP-25768
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
IDBP-478404
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
IDBP-485096
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
IDBP-484591
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
IDBP-475277
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
IDBP-477250
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
IDBP-481781
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
IDBP-479423
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
IDBP-810793
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
IDBP-810808
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 9918119
TCEB1 is a part of Elongin BC complex, and is a component of a multiprotein SOCS1 complex that attenuates JAK/STAT signalling by binding to JAK2 and inhibiting JAK2 kinase and by interacting with SOCS box, the Elongin BC complex can increase expression of the SOCS1 protein by inhibiting its degradation.
Entrez Gene
Summary This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:73939169-73972287
Strand Reverse strand
Band q21.11
Transcripts
ENST00000284811 ENSP00000284811
ENST00000518127 ENSP00000428334
ENST00000520210 ENSP00000430224
ENST00000520242 ENSP00000428171
ENST00000519487 ENSP00000429596
ENST00000522337 ENSP00000429906
ENST00000523815 ENSP00000428074
ENST00000519082 ENSP00000429789
ENST00000602840 ENSP00000473408
ENST00000622804 ENSP00000478121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 191 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 191 [view]
Protein-Protein 191 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010467 gene expression
GO:0016032 viral process
GO:0045087 innate immune response (InnateDB)
GO:0050434 positive regulation of viral transcription
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0070449 elongin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079658
View Gene Order
ENSBTAG00000002196
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_9453
Vif-mediated degradation of APOBEC3G pathway
REACT_6344
Tat-mediated HIV elongation arrest and recovery pathway
REACT_6143
Pausing and recovery of Tat-mediated HIV elongation pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6244
Pausing and recovery of HIV elongation pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6259
HIV elongation arrest and recovery pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_120956
Cellular responses to stress pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_75774
Adaptive Immune System pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6900
Immune System pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa05211
Renal cell carcinoma pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
hif2pathway
HIF-2-alpha transcription factor network
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.731928
RefSeq NM_001204857 NM_001204858 NM_001204859 NM_001204860 NM_001204861 NM_001204862 NM_001204863 NM_001204864 NM_005648 XM_005251290
HUGO
OMIM
CCDS CCDS34910 CCDS56539
HPRD 02875
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca