Version 5.4
Homo sapiens Gene: EIF4A1
Summary
InnateDB Gene IDBG-25777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4A1
Gene Name eukaryotic translation initiation factor 4A1
Synonyms DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I
Species Homo sapiens
Ensembl Gene ENSG00000161960
Encoded Proteins
IDBP-25781
eukaryotic translation initiation factor 4A1
IDBP-764343
IDBP-759734
IDBP-763207
IDBP-762688
IDBP-762335
IDBP-759921
IDBP-758726
IDBP-758261
IDBP-758943
IDBP-759627
IDBP-761562
IDBP-759866
IDBP-760975
IDBP-762271
IDBP-760374
IDBP-764238
IDBP-760920
IDBP-759235
IDBP-763508
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7572706-7579005
Strand Forward strand
Band p13.1
Transcripts
ENST00000293831 ENSP00000293831
ENST00000396527
ENST00000578569
ENST00000583802 ENSP00000463634
ENST00000577731
ENST00000580461 ENSP00000464320
ENST00000580888 ENSP00000462581
ENST00000578476 ENSP00000464082
ENST00000583899
ENST00000581808
ENST00000581384 ENSP00000464066
ENST00000582213
ENST00000582848
ENST00000583389 ENSP00000462719
ENST00000584860 ENSP00000462904
ENST00000579085
ENST00000581841
ENST00000585024 ENSP00000462275
ENST00000582050 ENSP00000463380
ENST00000577929 ENSP00000462372
ENST00000578495 ENSP00000464550
ENST00000582169 ENSP00000463309
ENST00000580886
ENST00000581770 ENSP00000462741
ENST00000577738
ENST00000584798
ENST00000578324
ENST00000581544 ENSP00000463821
ENST00000584054
ENST00000582746 ENSP00000462753
ENST00000584712
ENST00000579139 ENSP00000461921
ENST00000583217
ENST00000578754 ENSP00000463067
ENST00000584901
ENST00000577269 ENSP00000463486
ENST00000584784 ENSP00000463366
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 100 [view]
Protein-Protein 99 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000339 RNA cap binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003725 double-stranded RNA binding
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008135 translation factor activity, nucleic acid binding
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006200 ATP catabolic process
GO:0006412 translation
GO:0006413 translational initiation
GO:0008152 metabolic process
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0031100 organ regeneration
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059796
View Gene Order
ENSBTAG00000000132
Not yet available
Pathways
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_20514
Deadenylation of mRNA pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_1014
Translation pathway
REACT_25229
Interferon Signaling pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
mtor_4pathway
mTOR signaling pathway
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.614792 Hs.742408 Hs.742526
RefSeq NM_001204510 NM_001416
HUGO
OMIM
CCDS CCDS11113 CCDS58511
HPRD 04030
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca