Version 5.4
Homo sapiens Gene: PXDN
Summary
InnateDB Gene IDBG-25971.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PXDN
Gene Name peroxidasin homolog (Drosophila)
Synonyms COPOA; D2S448; D2S448E; MG50; PRG2; PXN; VPO
Species Homo sapiens
Ensembl Gene ENSG00000130508
Encoded Proteins
IDBP-25973
peroxidasin homolog (Drosophila)
IDBP-361875
peroxidasin homolog (Drosophila)
IDBP-361878
peroxidasin homolog (Drosophila)
IDBP-361882
peroxidasin homolog (Drosophila)
IDBP-361885
peroxidasin homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.[supplied by OMIM, Jul 2009]
This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:1631887-1744852
Strand Reverse strand
Band p25.3
Transcripts
ENST00000252804 ENSP00000252804
ENST00000453308 ENSP00000414098
ENST00000433670 ENSP00000402738
ENST00000447941 ENSP00000408701
ENST00000425171 ENSP00000398363
ENST00000493654
ENST00000478155
ENST00000477093
ENST00000493779
ENST00000465809
ENST00000467191
ENST00000483018
ENST00000477810
ENST00000485177
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005152 interleukin-1 receptor antagonist activity
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0006955 immune response
GO:0006979 response to oxidative stress
GO:0030198 extracellular matrix organization
GO:0042744 hydrogen peroxide catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020674
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.332197 Hs.598193 Hs.708927
RefSeq NM_012293 XM_005264707
HUGO
OMIM
CCDS CCDS46221
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca