Version 5.4
Homo sapiens Gene: TBC1D10B
Summary
InnateDB Gene IDBG-26054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBC1D10B
Gene Name TBC1 domain family, member 10B
Synonyms EPI64B
Species Homo sapiens
Ensembl Gene ENSG00000169221
Encoded Proteins
IDBP-295721
TBC1 domain family, member 10B
IDBP-749217
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30357102-30370264
Strand Reverse strand
Band p11.2
Transcripts
ENST00000409939 ENSP00000386538
ENST00000475650
ENST00000478158
ENST00000490703 ENSP00000456663
ENST00000475872
ENST00000464644
ENST00000566671
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042492
View Gene Order
ENSBTAG00000031852
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632182
RefSeq NM_015527
HUGO
OMIM
CCDS CCDS10676
HPRD 10892
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca