Version 5.4
Homo sapiens Gene: PKIA
Summary
InnateDB Gene IDBG-26102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKIA
Gene Name protein kinase (cAMP-dependent, catalytic) inhibitor alpha
Synonyms PRKACN1
Species Homo sapiens
Ensembl Gene ENSG00000171033
Encoded Proteins
IDBP-26104
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
IDBP-237561
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
IDBP-478954
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:78516139-78605267
Strand Forward strand
Band q21.13
Transcripts
ENST00000352966 ENSP00000336552
ENST00000396418 ENSP00000379696
ENST00000518467 ENSP00000430887
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004862 cAMP-dependent protein kinase inhibitor activity
GO:0005515 protein binding
GO:0034236 protein kinase A catalytic subunit binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0042308 negative regulation of protein import into nucleus
GO:0043086 negative regulation of catalytic activity
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027499
View Gene Order
ENSBTAG00000008150
Not yet available
Cross-References
SwissProt P61925
TrEMBL A0A024R7Y9
UniProt Splice Variant
Entrez Gene 5569
UniGene Hs.433700 Hs.630932
RefSeq NM_006823 NM_181839
HUGO HGNC:9017
OMIM 606059
CCDS CCDS6222
HPRD
IMGT
EMBL AF234641 BC022265 CH471068 CR457052 S76965
GenPept AAB21141 AAF40206 AAH22265 CAG33333 EAW87055 EAW87056 EAW87057 EAW87058
RNA Seq Atlas 5569

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca