Version 5.4
Homo sapiens Gene: ADI1
Summary
InnateDB Gene IDBG-26383.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADI1
Gene Name acireductone dioxygenase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182551
Encoded Proteins
IDBP-26385
acireductone dioxygenase 1
IDBP-26387
acireductone dioxygenase 1
IDBP-362110
acireductone dioxygenase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:3497361-3519736
Strand Reverse strand
Band p25.3
Transcripts
ENST00000382093 ENSP00000371525
ENST00000327435 ENSP00000333666
ENST00000415131 ENSP00000410178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006595 polyamine metabolic process
GO:0019509 L-methionine biosynthetic process from methylthioadenosine
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020629
View Gene Order
ENSBTAG00000005403
Not yet available
Pathways
NETPATH
REACTOME
REACT_75881
Methionine salvage pathway pathway
REACT_14820
Metabolism of polyamines pathway
REACT_115639
Sulfur amino acid metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00270
Cysteine and methionine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502773
RefSeq NM_018269 XM_005264696
HUGO
OMIM
CCDS CCDS1653
HPRD 17607
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca