Version 5.4
Mus musculus Gene: Eif5a
Summary
InnateDB Gene IDBG-264162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif5a
Gene Name eukaryotic translation initiation factor 5A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000078812
Encoded Proteins
IDBP-192755
eukaryotic translation initiation factor 5A
IDBP-192757
eukaryotic translation initiation factor 5A
IDBP-192759
eukaryotic translation initiation factor 5A
IDBP-264164
eukaryotic translation initiation factor 5A
IDBP-264166
eukaryotic translation initiation factor 5A
IDBP-264168
eukaryotic translation initiation factor 5A
IDBP-264170
eukaryotic translation initiation factor 5A
IDBP-264172
eukaryotic translation initiation factor 5A
IDBP-264174
eukaryotic translation initiation factor 5A
IDBP-264176
eukaryotic translation initiation factor 5A
IDBP-718867
IDBP-536624
eukaryotic translation initiation factor 5A
IDBP-628249
eukaryotic translation initiation factor 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69916714-69921958
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000071026 ENSMUSP00000068651
ENSMUST00000043419 ENSMUSP00000047008
ENSMUST00000070996 ENSMUSP00000067077
ENSMUST00000108613 ENSMUSP00000104253
ENSMUST00000108612 ENSMUSP00000104252
ENSMUST00000108611 ENSMUSP00000104251
ENSMUST00000108610 ENSMUSP00000104250
ENSMUST00000108609 ENSMUSP00000104249
ENSMUST00000108608 ENSMUSP00000104248
ENSMUST00000108607 ENSMUSP00000104247
ENSMUST00000153652 ENSMUSP00000137459
ENSMUST00000152589 ENSMUSP00000123402
ENSMUST00000164359 ENSMUSP00000132717
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0043022 ribosome binding
Biological Process
GO:0006452 translational frameshifting
GO:0007568 aging
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0015031 protein transport
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045901 positive regulation of translational elongation
GO:0045905 positive regulation of translational termination
GO:0051028 mRNA transport
GO:0051149 positive regulation of muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000253626
View Gene Order
ENSBTAG00000002018
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_229541
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_203391
Hypusine synthesis from eIF5A-lysine pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_205598
Hypusine synthesis from eIF5A-lysine pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_206715
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001166589 NM_001166590 NM_001166591 NM_001166592 NM_001166593 NM_001166594 NM_001166595 NM_001166596 NM_181582
OMIM
CCDS CCDS24923
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca