Version 5.4
Homo sapiens Gene: EIF3G
Summary
InnateDB Gene IDBG-26498.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3G
Gene Name eukaryotic translation initiation factor 3, subunit G
Synonyms eIF3-delta; EIF3-P42; eIF3-p44; EIF3S4
Species Homo sapiens
Ensembl Gene ENSG00000130811
Encoded Proteins
IDBP-26500
eukaryotic translation initiation factor 3, subunit G
IDBP-760742
IDBP-766106
IDBP-763394
IDBP-766193
IDBP-764334
IDBP-765236
IDBP-761066
IDBP-763769
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10115017-10119920
Strand Reverse strand
Band p13.2
Transcripts
ENST00000253108 ENSP00000253108
ENST00000593066 ENSP00000466943
ENST00000587168
ENST00000589454 ENSP00000466860
ENST00000593054 ENSP00000467187
ENST00000588709 ENSP00000465882
ENST00000587993 ENSP00000468313
ENST00000589458
ENST00000589674
ENST00000590158
ENST00000593095 ENSP00000465933
ENST00000587681
ENST00000590647
ENST00000587146 ENSP00000468159
ENST00000592485
ENST00000586151 ENSP00000465925
ENST00000589009
ENST00000590940
ENST00000587590
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 80 [view]
Protein-Protein 80 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000070319
View Gene Order
ENSBTAG00000002734
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt O75821
TrEMBL K7EL20 K7EL60 K7ENA8 K7ENH0 K7EP16 K7ER90 K7ERL8
UniProt Splice Variant
Entrez Gene 8666
UniGene Hs.529059
RefSeq NM_003755
HUGO HGNC:3274
OMIM 603913
CCDS CCDS12227
HPRD
IMGT
EMBL AC020931 AF020833 AF092453 AF094850 BC000733 BC008469 BT006889 U96074
GenPept AAB71866 AAC78728 AAG15396 AAG15419 AAH00733 AAH08469 AAP35535
RNA Seq Atlas 8666

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca