Homo sapiens Gene: WRAP53
Summary
InnateDB Gene IDBG-26580.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol WRAP53
Gene Name WD repeat containing, antisense to TP53
Synonyms DKCB3; TCAB1; WDR79;
Species Homo sapiens
Ensembl Gene ENSG00000141499
Encoded Proteins
WD repeat containing, antisense to TP53
WD repeat containing, antisense to TP53
WD repeat containing, antisense to TP53
WD repeat containing, antisense to TP53
WD repeat containing, antisense to TP53
WD repeat containing, antisense to TP53
Protein Structure
Entrez Gene
Summary This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7589389-7606820
Strand Forward strand
Band p13.1
Transcripts
ENST00000316024 ENSP00000324203
ENST00000396463 ENSP00000379727
ENST00000431639 ENSP00000397219
ENST00000457584 ENSP00000411061
ENST00000498311 ENSP00000432991
ENST00000467699
ENST00000463804 ENSP00000465025
ENST00000471973
ENST00000498114
ENST00000534050 ENSP00000434999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0032203 telomere formation via telomerase
GO:0051973 positive regulation of telomerase activity
Cellular Component
GO:0005634 nucleus
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Telomere Extension By Telomerase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9BUR4
TrEMBL C6ZGR0 E9PMG4 E9PMR3
UniProt Splice Variant
Entrez Gene 55135
UniGene Hs.408312 Hs.735124
RefSeq NM_001143990 NM_001143991 NM_001143992 NM_018081
HUGO 25522
OMIM 612661
CCDS CCDS11119
HPRD 07670
IMGT
EMBL AC087388 AK001247 AK056669 AY766322 BC002336 CH471108 DQ431240 DQ431241 EU876947 EU876948 EU876949 EU876953 EU876955 EU876957 EU876958 EU876959 EU876961 EU876962 EU876963 EU876964 EU876965 EU876966 EU876967 EU876968 EU876969 EU876970 EU876971 EU876973 EU876974 EU876975 EU876976 EU876977 EU876978 EU876979 EU876980 EU876981 EU876982 EU876983 EU876985 EU876986 EU876987 EU876988 EU876989 EU876992 EU876993 EU876994 EU876995 EU876996 EU876997 EU876998 EU876999 EU877000 EU877001 EU877002 EU877003 EU877004 EU877005 EU877006 EU877008 EU877010 EU877011 EU877012 EU877013 EU877014 EU877015 EU877017 EU877018 EU877019 EU877021 EU877023 EU877027 EU877028 EU877031 EU877033 EU877042 EU877046 EU877051 EU877053
GenPept AAH02336 AAW92115 ABD92817 ABD92818 ACM07586 ACM07587 ACM07588 ACM07592 ACM07594 ACM07596 ACM07597 ACM07598 ACM07600 ACM07601 ACM07602 ACM07603 ACM07604 ACM07605 ACM07606 ACM07607 ACM07608 ACM07609 ACM07610 ACM07612 ACM07613 ACM07614 ACM07615 ACM07616 ACM07617 ACM07618 ACM07619 ACM07620 ACM07621 ACM07622 ACM07624 ACM07625 ACM07626 ACM07627 ACM07628 ACM07631 ACM07632 ACM07633 ACM07634 ACM07635 ACM07636 ACM07637 ACM07638 ACM07639 ACM07640 ACM07641 ACM07642 ACM07643 ACM07644 ACM07645 ACM07647 ACM07649 ACM07650 ACM07651 ACM07652 ACM07653 ACM07654 ACM07656 ACM07657 ACM07658 ACM07660 ACM07662 ACM07666 ACM07667 ACM07670 ACM07672 ACM07681 ACM07685 ACM07690 ACM07692 BAA91579 BAG51781 EAW90136 EAW90138 EAW90139
ImmGen WRAP53 (murine)
RNA Seq Atlas 55135