Version 5.4
Homo sapiens Gene: EFNB3
Summary
InnateDB Gene IDBG-26628.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFNB3
Gene Name ephrin-B3
Synonyms EFL6; EPLG8; LERK8
Species Homo sapiens
Ensembl Gene ENSG00000108947
Encoded Proteins
IDBP-26632
ephrin-B3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7705202-7711378
Strand Forward strand
Band p13.1
Transcripts
ENST00000226091 ENSP00000226091
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005005 transmembrane-ephrin receptor activity
GO:0046875 ephrin receptor binding
Biological Process
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007628 adult walking behavior
GO:0016032 viral process
GO:0016198 axon choice point recognition
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003934
View Gene Order
ENSBTAG00000037604
Not yet available
Pathways
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_18266
Axon guidance pathway
REACT_228226
Ephrin signaling pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt Q15768
TrEMBL
UniProt Splice Variant
Entrez Gene 1949
UniGene Hs.26988
RefSeq NM_001406
HUGO HGNC:3228
OMIM 602297
CCDS CCDS11120
HPRD
IMGT
EMBL AK314841 BC022499 BC042944 CH471108 U57001 U62775 U66406
GenPept AAB05170 AAC50707 AAC51203 AAH22499 AAH42944 BAG37359 EAW90133 EAW90135
RNA Seq Atlas 1949

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca