Version 5.4
Homo sapiens Gene: SLC25A15
Summary
InnateDB Gene IDBG-26653.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A15
Gene Name solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
Synonyms D13S327; HHH; ORC1; ORNT1
Species Homo sapiens
Ensembl Gene ENSG00000102743
Encoded Proteins
IDBP-26657
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
IDBP-365929
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
IDBP-597928
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:40789412-40810111
Strand Forward strand
Band q14.11
Transcripts
ENST00000338625 ENSP00000342267
ENST00000417731 ENSP00000415826
ENST00000478827
ENST00000470509 ENSP00000431429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000064 L-ornithine transmembrane transporter activity
Biological Process
GO:0000050 urea cycle
GO:0000066 mitochondrial ornithine transport
GO:0006520 cellular amino acid metabolic process
GO:0006810 transport
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031482
View Gene Order
ENSBTAG00000011647
Not yet available
Pathways
NETPATH
REACTOME
REACT_847
Urea cycle pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_014252
HUGO
OMIM
CCDS CCDS9373
HPRD 04838
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca