Homo sapiens Gene: SLC25A15
Summary
InnateDB Gene IDBG-26653.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol SLC25A15
Gene Name solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
Synonyms D13S327; HHH; ORC1; ORNT1;
Species Homo sapiens
Ensembl Gene ENSG00000102743
Encoded Proteins
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
Protein Structure
Entrez Gene
Summary This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:41363548-41386596
Strand Forward strand
Band q14.11
Transcripts
ENST00000338625 ENSP00000342267
ENST00000426521 ENSP00000431313
ENST00000417731 ENSP00000415826
ENST00000478827
ENST00000470509 ENSP00000431429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000064 L-ornithine transmembrane transporter activity
Biological Process
GO:0000050 urea cycle
GO:0000066 mitochondrial ornithine transport
GO:0006520 cellular amino acid metabolic process
GO:0006810 transport
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Urea cycle pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y619
TrEMBL F2Z354 Q5VZD9
UniProt Splice Variant
Entrez Gene 10166
UniGene
RefSeq
HUGO 10985
OMIM 603861
CCDS CCDS9373
HPRD 04838
IMGT
EMBL AF112968 AF177333 AJ309943 AL161614 BC002702 CH471075
GenPept AAD45238 AAG17977 AAH02702 CAC83972 CAH72773 CAH72774 EAX08630
ImmGen SLC25A15 (murine)
RNA Seq Atlas 10166