Homo sapiens Gene: MRPL4
Summary
InnateDB Gene IDBG-26718.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL4
Gene Name mitochondrial ribosomal protein L4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105364
Encoded Proteins
mitochondrial ribosomal protein L4
mitochondrial ribosomal protein L4
mitochondrial ribosomal protein L4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10251901-10260045
Strand Forward strand
Band p13.2
Transcripts
ENST00000253099 ENSP00000253099
ENST00000307422 ENSP00000306902
ENST00000393733 ENSP00000377334
ENST00000588502 ENSP00000466169
ENST00000590150 ENSP00000466050
ENST00000592071
ENST00000591054 ENSP00000465635
ENST00000590702 ENSP00000465050
ENST00000588963
ENST00000590669 ENSP00000465143
ENST00000592514 ENSP00000468569
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9BYD3
TrEMBL A0A024R7C5 K7EJ73 K7ES61
UniProt Splice Variant
Entrez Gene 51073
UniGene Hs.279652
RefSeq NM_015956 NM_146387 NM_146388
HUGO HGNC:14276
OMIM 611823
CCDS CCDS12230 CCDS42499
HPRD 14759
IMGT
EMBL AB049635 AC011511 AF132962 AY007152 BC000756 BC009858 CH471106
GenPept AAD27737 AAG02005 AAH00756 AAH09858 BAB40840 EAW84083 EAW84084
RNA Seq Atlas 51073