Version 5.4
Homo sapiens Gene: IMPA1
Summary
InnateDB Gene IDBG-26796.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IMPA1
Gene Name inositol(myo)-1(or 4)-monophosphatase 1
Synonyms IMP; IMPA
Species Homo sapiens
Ensembl Gene ENSG00000133731
Encoded Proteins
IDBP-26792
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-26798
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-372882
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-482989
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-481113
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-479113
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-475400
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-477511
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-479311
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-480957
inositol(myo)-1(or 4)-monophosphatase 1
IDBP-475463
inositol(myo)-1(or 4)-monophosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]
This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2\'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:81657961-81686693
Strand Reverse strand
Band q21.13
Transcripts
ENST00000311489 ENSP00000311803
ENST00000256108 ENSP00000256108
ENST00000449740 ENSP00000408526
ENST00000523942 ENSP00000429735
ENST00000518188 ENSP00000428812
ENST00000523710
ENST00000519964 ENSP00000429322
ENST00000521360 ENSP00000430283
ENST00000520065
ENST00000521979 ENSP00000428425
ENST00000522997 ENSP00000430081
ENST00000518202 ENSP00000429516
ENST00000519816 ENSP00000428594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008934 inositol monophosphate 1-phosphatase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0052832 inositol monophosphate 3-phosphatase activity
GO:0052833 inositol monophosphate 4-phosphatase activity
Biological Process
GO:0006021 inositol biosynthetic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006796 phosphate-containing compound metabolic process
GO:0007165 signal transduction
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0046855 inositol phosphate dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027531
View Gene Order
ENSBTAG00000011709
Not yet available
Pathways
NETPATH
REACTOME
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL E5RIF4
UniProt Splice Variant
Entrez Gene 3612
UniGene
RefSeq NM_001144878 NM_001144879 NM_005536
HUGO HGNC:6050
OMIM 602064
CCDS CCDS47883 CCDS47884 CCDS6231
HPRD 03641
IMGT
EMBL AC090255
GenPept
RNA Seq Atlas 3612

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca