InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PIK3C3

Summary

InnateDB Gene

IDBG-2711.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3C3

Gene Name

phosphatidylinositol 3-kinase, catalytic subunit type 3

Synonyms

hVps34; VPS34

Species

Homo sapiens

Ensembl Gene

ENSG00000078142

Encoded Proteins

IDBP-2713

phosphoinositide-3-kinase, class 3

IDBP-232020

phosphoinositide-3-kinase, class 3

IDBP-728079

IDBP-727843

IDBP-725663

IDBP-725650

IDBP-725584

IDBP-727931

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22170068

Class III phosphatidylinositol 3-kinases (PI3K) are required for downstream ARF6 regulation of CpG oligodeoxynucleotide uptake and thus have a role in TLR9-mediated immune signalling.

InnateDB Annotation from Orthologs

Summary

PMID 22170068

[Mus musculus] Class III phosphatidylinositol 3-kinases (PI3K) are required for downstream Arf6 regulation of CpG oligodeoxynucleotide uptake and thus have a role in Tlr9-mediated immune signalling.

PMID 25586187

[Mus musculus] Super-low dose lipopolysaccharide induces inhibitory phosphorylation of Pik3c3 leading to the disruption of endosome-lysosome fusion and low-grade inflammation in innate macrophages; a mechanism that depends on the clearance and relocation of Tollip.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:41955206-42087830

Strand

Forward strand

Band

q12.3

Transcripts

ENST00000262039	ENSP00000262039
ENST00000398870	ENSP00000381845
ENST00000585528	ENSP00000464909
ENST00000587328
ENST00000590013
ENST00000587402	ENSP00000473061
ENST00000593098
ENST00000589056	ENSP00000471957
ENST00000587261
ENST00000597477	ENSP00000472926
ENST00000589550
ENST00000591011	ENSP00000466946
ENST00000588631
ENST00000590220
ENST00000588156
ENST00000586545	ENSP00000465621

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	47 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0035004	phosphatidylinositol 3-kinase activity

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000910	cytokinesis
GO:0002224	toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007032	endosome organization
GO:0008286	insulin receptor signaling pathway
GO:0016485	protein processing
GO:0034162	toll-like receptor 9 signaling pathway
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0043201	response to leucine
GO:0044281	small molecule metabolic process
GO:0045022	early endosome to late endosome transport
GO:0045087	innate immune response (InnateDB)
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050708	regulation of protein secretion

Cellular Component

GO:0005770	late endosome
GO:0005829	cytosol
GO:0005930	axoneme
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0016020	membrane
GO:0030496	midbody
GO:0045335	phagocytic vesicle