Homo sapiens Gene: ID2
Summary
InnateDB Gene IDBG-27111.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ID2
Gene Name inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Synonyms bHLHb26; GIG8; ID2A; ID2H;
Species Homo sapiens
Ensembl Gene ENSG00000115738
Encoded Proteins
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Group 3 innate lymphoid cells (ILC3s) can mediate immune surveillance, which constantly maintains a proper microbiota, to facilitate early colonization resistance through an Id2-dependent regulation of Il22.
[Mus musculus] Group 3 innate lymphoid cells (ILC3s) can mediate immune surveillance, which constantly maintains a proper microbiota, to facilitate early colonization resistance through an Id2-dependent regulation of Il22.
Entrez Gene
Summary The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:8678845-8684453
Strand Forward strand
Band p25.1
Transcripts
ENST00000234091 ENSP00000234091
ENST00000331129 ENSP00000385465
ENST00000396290 ENSP00000379585
ENST00000472142
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044325 ion channel binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001656 metanephros development
GO:0001779 natural killer cell differentiation
GO:0002521 leukocyte differentiation
GO:0003149 membranous septum morphogenesis
GO:0003166 bundle of His development
GO:0007275 multicellular organismal development
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0009649 entrainment of circadian clock
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014003 oligodendrocyte development
GO:0019216 regulation of lipid metabolic process
GO:0021772 olfactory bulb development
GO:0032922 circadian regulation of gene expression
GO:0033598 mammary gland epithelial cell proliferation
GO:0042752 regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043353 enucleate erythrocyte differentiation
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045475 locomotor rhythm
GO:0045578 negative regulation of B cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045777 positive regulation of blood pressure
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048468 cell development
GO:0048469 cell maturation
GO:0048541 Peyer's patch development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048663 neuron fate commitment
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0060612 adipose tissue development
GO:0060749 mammary gland alveolus development
GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development
GO:0061031 endodermal digestive tract morphogenesis
GO:0071158 positive regulation of cell cycle arrest
GO:0071285 cellular response to lithium ion
GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0090398 cellular senescence
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
ID pathway
REACTOME
KEGG
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
Validated targets of C-MYC transcriptional activation
Regulation of nuclear beta catenin signaling and target gene transcription
HIF-1-alpha transcription factor network
Cross-References
SwissProt Q02363
TrEMBL Q53T66
UniProt Splice Variant
Entrez Gene 3398
UniGene Hs.180919 Hs.596938 Hs.665350
RefSeq NM_002166
HUGO HGNC:5361
OMIM 600386
CCDS CCDS1659
HPRD 02664
IMGT
EMBL AC011747 AK311988 AY634687 BC030639 CH471053 D13891 M97796
GenPept AAA58681 AAH30639 AAV35470 AAY14810 BAA02990 BAG34927 EAX01018 EAX01019
RNA Seq Atlas 3398