Version 5.4
Homo sapiens Gene: ID2
Summary
InnateDB Gene IDBG-27111.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ID2
Gene Name inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Synonyms bHLHb26; GIG8; ID2A; ID2H
Species Homo sapiens
Ensembl Gene ENSG00000115738
Encoded Proteins
IDBP-27113
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDBP-292706
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDBP-237833
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25902484
[Mus musculus] Group 3 innate lymphoid cells (ILC3s) can mediate immune surveillance, which constantly maintains a proper microbiota, to facilitate early colonization resistance through an Id2-dependent regulation of Il22.
PMID 25902484
[Mus musculus] Group 3 innate lymphoid cells (ILC3s) can mediate immune surveillance, which constantly maintains a proper microbiota, to facilitate early colonization resistance through an Id2-dependent regulation of Il22.
Entrez Gene
Summary The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:8678845-8684453
Strand Forward strand
Band p25.1
Transcripts
ENST00000234091 ENSP00000234091
ENST00000331129 ENSP00000385465
ENST00000396290 ENSP00000379585
ENST00000472142
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044325 ion channel binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001656 metanephros development
GO:0001779 natural killer cell differentiation
GO:0002521 leukocyte differentiation
GO:0003149 membranous septum morphogenesis
GO:0003166 bundle of His development
GO:0007275 multicellular organismal development
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0009649 entrainment of circadian clock
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014003 oligodendrocyte development
GO:0019216 regulation of lipid metabolic process
GO:0021772 olfactory bulb development
GO:0032922 circadian regulation of gene expression
GO:0033598 mammary gland epithelial cell proliferation
GO:0042752 regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043353 enucleate erythrocyte differentiation
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045475 locomotor rhythm
GO:0045578 negative regulation of B cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045777 positive regulation of blood pressure
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048468 cell development
GO:0048469 cell maturation
GO:0048541 Peyer's patch development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048663 neuron fate commitment
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0060612 adipose tissue development
GO:0060749 mammary gland alveolus development
GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development
GO:0061031 endodermal digestive tract morphogenesis
GO:0071158 positive regulation of cell cycle arrest
GO:0071285 cellular response to lithium ion
GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0090398 cellular senescence
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020644
View Gene Order
ENSBTAG00000021187
Not yet available
Pathways
NETPATH
NetPath_5
ID pathway
REACTOME
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
myc_activpathway
Validated targets of C-MYC transcriptional activation
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.180919 Hs.596938 Hs.665350
RefSeq NM_002166
HUGO
OMIM
CCDS CCDS1659
HPRD 02664
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca