Version 5.4
Homo sapiens Gene: CA1
Summary
InnateDB Gene IDBG-27139.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CA1
Gene Name carbonic anhydrase I
Synonyms CA-I; CAB; Car1; HEL-S-11
Species Homo sapiens
Ensembl Gene ENSG00000133742
Encoded Proteins
IDBP-373032
carbonic anhydrase I
IDBP-478654
carbonic anhydrase I
IDBP-477112
carbonic anhydrase I
IDBP-474156
carbonic anhydrase I
IDBP-476771
carbonic anhydrase I
IDBP-483534
carbonic anhydrase I
IDBP-482835
carbonic anhydrase I
IDBP-476516
carbonic anhydrase I
IDBP-480398
carbonic anhydrase I
IDBP-480889
carbonic anhydrase I
IDBP-478135
carbonic anhydrase I
IDBP-474932
carbonic anhydrase I
IDBP-481451
carbonic anhydrase I
IDBP-478261
carbonic anhydrase I
IDBP-480438
carbonic anhydrase I
IDBP-484329
carbonic anhydrase I
IDBP-482216
carbonic anhydrase I
IDBP-588631
carbonic anhydrase I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature. [provided by RefSeq, Sep 2009]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:85327608-85379014
Strand Reverse strand
Band q21.2
Transcripts
ENST00000431316 ENSP00000392338
ENST00000523953 ENSP00000430656
ENST00000523022 ENSP00000429798
ENST00000522389 ENSP00000427773
ENST00000521679 ENSP00000429300
ENST00000524324 ENSP00000428923
ENST00000517618 ENSP00000430861
ENST00000519991 ENSP00000430543
ENST00000523712
ENST00000520663 ENSP00000430571
ENST00000517590 ENSP00000429843
ENST00000518233
ENST00000517429 ENSP00000430710
ENST00000521846 ENSP00000430471
ENST00000522579 ENSP00000427852
ENST00000518341
ENST00000522814 ENSP00000430737
ENST00000522662 ENSP00000430372
ENST00000523858 ENSP00000430975
ENST00000520093
ENST00000520990
ENST00000519129 ENSP00000429688
ENST00000520692
ENST00000542576 ENSP00000443517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0015701 bicarbonate transport
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000027556
View Gene Order
Pathways
NETPATH
REACTOME
REACT_121123
Reversible hydration of carbon dioxide pathway
REACT_121380
Erythrocytes take up oxygen and release carbon dioxide pathway
REACT_121329
Erythrocytes take up carbon dioxide and release oxygen pathway
REACT_120969
O2/CO2 exchange in erythrocytes pathway
REACT_111217
Metabolism pathway
KEGG
hsa00910
Nitrogen metabolism pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt P00915
TrEMBL E5RFE7 E5RFL2 E5RG43 E5RG81 E5RGU8 E5RH81 E5RHP7 E5RHS7 E5RIF9 E5RII2 E5RJF6 E5RJI8 V9HWE3
UniProt Splice Variant
Entrez Gene 759
UniGene Hs.23118
RefSeq NM_001128829 NM_001128830 NM_001128831 NM_001164830 NM_001738
HUGO HGNC:1368
OMIM 114800
CCDS CCDS6237
HPRD
IMGT
EMBL AC025800 BC027890 CH471068 EU794595 M33987 X05014
GenPept AAA51910 AAH27890 ACJ13649 CAA28663 EAW87129 EAW87130 EAW87131 EAW87132
RNA Seq Atlas 759

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca