InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC37

Summary

InnateDB Gene

IDBG-27267.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC37

Gene Name

cell division cycle 37 homolog (S. cerevisiae)

Synonyms

P50CDC37

Species

Homo sapiens

Ensembl Gene

ENSG00000105401

Encoded Proteins

IDBP-27269

cell division cycle 37 homolog (S. cerevisiae)

IDBP-762363

IDBP-762763

IDBP-765933

IDBP-761187

IDBP-765813

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10391134-10420121

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000222005	ENSP00000222005
ENST00000589331	ENSP00000464889
ENST00000588498
ENST00000589755
ENST00000589625	ENSP00000465941
ENST00000589629	ENSP00000467747
ENST00000593124	ENSP00000465724
ENST00000588869	ENSP00000464971
ENST00000591248
ENST00000590632

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 273 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	273 [view]
Protein-Protein	272 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031072	heat shock protein binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0043422	protein kinase B binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006605	protein targeting
GO:0051726	regulation of cell cycle
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway