Version 5.4
Homo sapiens Gene: FBXL19
Summary
InnateDB Gene IDBG-27288.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL19
Gene Name F-box and leucine-rich repeat protein 19
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099364
Encoded Proteins
IDBP-27290
F-box and leucine-rich repeat protein 19
IDBP-27292
F-box and leucine-rich repeat protein 19
IDBP-375631
F-box and leucine-rich repeat protein 19
IDBP-750959
IDBP-753150
IDBP-753719
IDBP-746105
IDBP-750781
IDBP-753703
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to the transmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30923055-30948783
Strand Forward strand
Band p11.2
Transcripts
ENST00000380310 ENSP00000369666
ENST00000338343 ENSP00000339712
ENST00000427128 ENSP00000397913
ENST00000471231 ENSP00000458033
ENST00000565939 ENSP00000457199
ENST00000562319 ENSP00000455529
ENST00000565690 ENSP00000454344
ENST00000566320 ENSP00000455337
ENST00000562798 ENSP00000455871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030811
View Gene Order
ENSBTAG00000040555
Not yet available
Cross-References
SwissProt
TrEMBL H3BVB1
UniProt Splice Variant
Entrez Gene 54620
UniGene Hs.152149
RefSeq NM_001282351 NM_001099784
HUGO HGNC:25300
OMIM 609085
CCDS CCDS73873 CCDS45465
HPRD 12366
IMGT
EMBL AC135048
GenPept
RNA Seq Atlas 54620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca