InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGB1BP1

Summary

InnateDB Gene

IDBG-27498.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB1BP1

Gene Name

integrin beta 1 binding protein 1

Synonyms

ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1; ICAP1A; ICAP1B

Species

Homo sapiens

Ensembl Gene

ENSG00000119185

Encoded Proteins

IDBP-27500

integrin beta 1 binding protein 1

IDBP-27502

integrin beta 1 binding protein 1

IDBP-27504

integrin beta 1 binding protein 1

IDBP-27506

integrin beta 1 binding protein 1

IDBP-362925

integrin beta 1 binding protein 1

IDBP-593319

integrin beta 1 binding protein 1

IDBP-475256

integrin beta 1 binding protein 1

IDBP-485327

integrin beta 1 binding protein 1

IDBP-477203

integrin beta 1 binding protein 1

IDBP-480774

integrin beta 1 binding protein 1

IDBP-476641

integrin beta 1 binding protein 1

IDBP-476236

integrin beta 1 binding protein 1

IDBP-479999

integrin beta 1 binding protein 1

IDBP-478366

integrin beta 1 binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:9403475-9423547

Strand

Reverse strand

Band

p25.1

Transcripts

ENST00000360635	ENSP00000353850
ENST00000359712	ENSP00000352743
ENST00000355346	ENSP00000347504
ENST00000238091	ENSP00000238091
ENST00000456913	ENSP00000389704
ENST00000483795	ENSP00000433814
ENST00000490426
ENST00000497031
ENST00000464228	ENSP00000419452
ENST00000465527
ENST00000460720
ENST00000488451	ENSP00000419524
ENST00000470507
ENST00000482798
ENST00000492079	ENSP00000420770
ENST00000463190
ENST00000494563	ENSP00000417940
ENST00000467606	ENSP00000419814
ENST00000484735	ENSP00000418526
ENST00000460001	ENSP00000417850
ENST00000497105	ENSP00000418947

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005092	GDP-dissociation inhibitor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding

Biological Process

GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006469	negative regulation of protein kinase activity
GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007160	cell-matrix adhesion
GO:0007219	Notch signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010595	positive regulation of endothelial cell migration
GO:0010764	negative regulation of fibroblast migration
GO:0015031	protein transport
GO:0016477	cell migration
GO:0030154	cell differentiation
GO:0031214	biomineral tissue development
GO:0032091	negative regulation of protein binding
GO:0032148	activation of protein kinase B activity
GO:0033622	integrin activation
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0035148	tube formation
GO:0035556	intracellular signal transduction
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0043088	regulation of Cdc42 GTPase activity
GO:0043113	receptor clustering
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050880	regulation of blood vessel size
GO:0051451	myoblast migration
GO:0051496	positive regulation of stress fiber assembly
GO:0051781	positive regulation of cell division
GO:0051894	positive regulation of focal adhesion assembly
GO:0051895	negative regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:0090314	positive regulation of protein targeting to membrane
GO:0090315	negative regulation of protein targeting to membrane
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
GO:2001044	regulation of integrin-mediated signaling pathway

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000062352

View Gene Order

ENSBTAG00000013063

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.467662 Hs.695627

RefSeq

NM_004763 NM_022334 XM_005246183 XM_005246184 XM_005246185 XM_005246186 XM_005246187 XM_005246189 XM_006711903

HUGO

OMIM

CCDS

CCDS1662 CCDS1663

HPRD

06194

IMGT

EMBL

GenPept

RNA Seq Atlas