Version 5.4
Homo sapiens Gene: LIN54
Summary
InnateDB Gene IDBG-27546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIN54
Gene Name lin-54 homolog (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000189308
Encoded Proteins
IDBP-27548
lin-54 homolog (C. elegans)
IDBP-373146
lin-54 homolog (C. elegans)
IDBP-373147
lin-54 homolog (C. elegans)
IDBP-479447
lin-54 homolog (C. elegans)
IDBP-484534
lin-54 homolog (C. elegans)
IDBP-482095
lin-54 homolog (C. elegans)
IDBP-484107
lin-54 homolog (C. elegans)
IDBP-481267
lin-54 homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:82909973-83012926
Strand Reverse strand
Band q21.22
Transcripts
ENST00000340417 ENSP00000341947
ENST00000446851 ENSP00000407139
ENST00000442461 ENSP00000398265
ENST00000505905
ENST00000510877 ENSP00000421651
ENST00000510557 ENSP00000421045
ENST00000508171 ENSP00000427413
ENST00000506560 ENSP00000423475
ENST00000505397 ENSP00000425844
ENST00000509748
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035310
View Gene Order
ENSBTAG00000010546
Not yet available
Pathways
NETPATH
REACTOME
REACT_111214
G0 and Early G1 pathway
REACT_1006
Polo-like kinase mediated events pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.96952
RefSeq NM_001115007 NM_001115008 NM_001288996 NM_001288997 NM_194282 XM_005262749 XM_005262750 XM_005262752 XM_006714081
HUGO
OMIM
CCDS CCDS3599 CCDS47089 CCDS75157
HPRD 13218
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca