Version 5.4
Homo sapiens Gene: COPS4
Summary
InnateDB Gene IDBG-27575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS4
Gene Name COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138663
Encoded Proteins
IDBP-27577
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
IDBP-477835
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
IDBP-483667
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
IDBP-485356
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
IDBP-481672
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
IDBP-479924
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:83034447-83075818
Strand Forward strand
Band q21.22
Transcripts
ENST00000264389 ENSP00000264389
ENST00000509093 ENSP00000425976
ENST00000511891
ENST00000509317 ENSP00000425486
ENST00000510801
ENST00000506443
ENST00000507376 ENSP00000426788
ENST00000503682 ENSP00000424791
ENST00000511653 ENSP00000424655
ENST00000511708
ENST00000504274
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 110 [view]
Protein-Protein 110 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000338 protein deneddylation
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0008021 synaptic vesicle
GO:0008180 COP9 signalosome
GO:0030054 cell junction
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035297
View Gene Order
ENSBTAG00000006950
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.190384 Hs.684069
RefSeq NM_001258006 NM_016129
HUGO
OMIM
CCDS CCDS3600 CCDS58909
HPRD 09888
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca