Homo sapiens Gene: SEC11A
Summary
InnateDB Gene IDBG-27714.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC11A
Gene Name SEC11 homolog A (S. cerevisiae)
Synonyms 1810012E07Rik; SEC11L1; sid2895; SPC18; SPCS4A
Species Homo sapiens
Ensembl Gene ENSG00000140612
Encoded Proteins
SEC11 homolog A (S. cerevisiae)
SEC11 homolog A (S. cerevisiae)
SEC11 homolog A (S. cerevisiae)
SEC11 homolog A (S. cerevisiae)
SEC11 homolog A (S. cerevisiae)
SEC11 homolog A (S. cerevisiae)
SEC11 homolog A (S. cerevisiae)
SEC11 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:84669538-84716716
Strand Reverse strand
Band q25.3
Transcripts
ENST00000268220 ENSP00000268220
ENST00000455959 ENSP00000413121
ENST00000559376
ENST00000558134 ENSP00000452697
ENST00000560266 ENSP00000452684
ENST00000558217 ENSP00000453930
ENST00000558924
ENST00000560409 ENSP00000453997
ENST00000559729 ENSP00000452932
ENST00000558196 ENSP00000454193
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006412 translation
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Synthesis, secretion, and deacylation of Ghrelin pathway
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Translation pathway
Incretin synthesis, secretion, and inactivation pathway
Metabolism of proteins pathway
Peptide hormone metabolism pathway
Gene Expression pathway
KEGG
Protein export pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YNG3 H0YNX5
UniProt Splice Variant
Entrez Gene 23478
UniGene Hs.593290 Hs.9534
RefSeq NM_001271918 NM_001271919 NM_001271920 NM_001271921 NM_001271922 NM_014300
HUGO HGNC:17718
OMIM
CCDS CCDS45340 CCDS61742 CCDS61743 CCDS61744 CCDS73776
HPRD 07503
IMGT
EMBL AC087732 AC115102
GenPept
RNA Seq Atlas 102723931 23478