Version 5.4
Homo sapiens Gene: PON2
Summary
InnateDB Gene IDBG-27758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PON2
Gene Name paraoxonase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105854
Encoded Proteins
IDBP-27760
paraoxonase 2
IDBP-382284
paraoxonase 2
IDBP-382287
paraoxonase 2
IDBP-382293
paraoxonase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:95404867-95435198
Strand Reverse strand
Band q21.3
Transcripts
ENST00000222572 ENSP00000222572
ENST00000433091 ENSP00000404622
ENST00000455123 ENSP00000414515
ENST00000446142 ENSP00000405211
ENST00000483292
ENST00000459842
ENST00000469926
ENST00000491069
ENST00000490778
ENST00000493290
ENST00000478801
ENST00000460873
ENST00000493469
ENST00000471883
ENST00000469716
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004064 arylesterase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006979 response to oxidative stress
GO:0008152 metabolic process
GO:0019439 aromatic compound catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032667
View Gene Order
ENSBTAG00000008361
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.735870
RefSeq NM_000305 NM_001018161
HUGO
OMIM
CCDS CCDS47644 CCDS5640
HPRD 03903
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca