Version 5.4
Homo sapiens Gene: ADAMTS20
Summary
InnateDB Gene IDBG-27897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAMTS20
Gene Name ADAM metallopeptidase with thrombospondin type 1 motif, 20
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173157
Encoded Proteins
IDBP-27899
ADAM metallopeptidase with thrombospondin type 1 motif, 20
IDBP-239311
ADAM metallopeptidase with thrombospondin type 1 motif, 20
IDBP-603171
ADAM metallopeptidase with thrombospondin type 1 motif, 20
IDBP-596982
ADAM metallopeptidase with thrombospondin type 1 motif, 20
IDBP-810608
ADAM metallopeptidase with thrombospondin type 1 motif, 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:43353866-43551921
Strand Reverse strand
Band q12
Transcripts
ENST00000389420 ENSP00000374071
ENST00000395541 ENSP00000378911
ENST00000549670 ENSP00000447427
ENST00000553158 ENSP00000448341
ENST00000615814 ENSP00000484172
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0009967 positive regulation of signal transduction
GO:0030198 extracellular matrix organization
GO:0043066 negative regulation of apoptotic process
GO:0045636 positive regulation of melanocyte differentiation
GO:0048070 regulation of developmental pigmentation
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022449
View Gene Order
ENSBTAG00000000395
Not yet available
Pathways
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.287554
RefSeq NM_025003
HUGO
OMIM
CCDS CCDS31778
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca