InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC25A13

Summary

InnateDB Gene

IDBG-27955.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A13

Gene Name

solute carrier family 25 (aspartate/glutamate carrier), member 13

Synonyms

ARALAR2; CITRIN; CTLN2

Species

Homo sapiens

Ensembl Gene

ENSG00000004864

Encoded Proteins

IDBP-27957

solute carrier family 25, member 13 (citrin)

IDBP-382389

solute carrier family 25, member 13 (citrin)

IDBP-813202

solute carrier family 25 (aspartate/glutamate carrier), member 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:96120220-96322147

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000265631	ENSP00000265631
ENST00000416240	ENSP00000400101
ENST00000494085
ENST00000490072
ENST00000484495
ENST00000492869
ENST00000472162	ENSP00000473505
ENST00000487710

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	26 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005509	calcium ion binding
GO:0015183	L-aspartate transmembrane transporter activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006754	ATP biosynthetic process
GO:0006810	transport
GO:0015810	aspartate transport
GO:0015813	L-glutamate transport
GO:0043490	malate-aspartate shuttle
GO:0044281	small molecule metabolic process
GO:0045333	cellular respiration
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport