Homo sapiens Gene: SLC25A13

Summary
InnateDB Gene IDBG-27955.6
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol SLC25A13
Gene Name solute carrier family 25 (aspartate/glutamate carrier), member 13
Synonyms ARALAR2; CITRIN; CTLN2
Species Homo sapiens
Ensembl Gene ENSG00000004864
Encoded Proteins
IDBP-27957 solute carrier family 25, member 13 (citrin)
IDBP-382389 solute carrier family 25, member 13 (citrin)
IDBP-595724 solute carrier family 25, member 13 (citrin)
Entrez Gene
Summary This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7: 95749532-95951459
Strand Reverse strand
Band q21.3
Transcripts
ENST00000265631  ENSP00000265631
ENST00000416240  ENSP00000400101
ENST00000494085 
ENST00000490072 
ENST00000484495 
ENST00000492869 
ENST00000472162 
ENST00000487710 
ENST00000542654  ENSP00000440484
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein‑Protein  20
[view]
Protein‑DNA 2
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005215 transporter activity
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005509 calcium ion binding
GO:0015183 L-aspartate transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006754 ATP biosynthetic process
GO:0006810 transport
GO:0015810 aspartate transport
GO:0015813 L-glutamate transport
GO:0043490 malate-aspartate shuttle
GO:0044281 small molecule metabolic process
GO:0045333 cellular respiration
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005887 integral to plasma membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000015112 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000003773 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_1520 Gluconeogenesis
REACT_118595 Mitochondrial Protein Import
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UJS0 
TrEMBL F5GX33 Q75KX8
UniProt Splice Variant
Entrez Gene 10165 
UniGene Hs.489190
RefSeq NM_001160210  NM_014251 
HUGO 10983 
OMIM 603859
CCDS CCDS55130  CCDS5645 
HPRD 04837
IMGT
EMBL AC002450 AC002540 AC004458 AC084368 AC096775 AF118838 AH009104 AJ496569 BC006566 CH471091 Y17571
GenPept AAB67049  AAB70112  AAD38501  AAF28473  AAH06566  AAS07527  CAB62206  CAD43091  EAW76748 
ImmGen SLC25A13 (murine) 
RNA Seq Atlas 10165