InnateDB: Systems Biology of the Innate Immune Response

ILF3 is an RNA-binding protein that influences mRNA turnover and/or translation by regulating mRNA stability. ILF3 can bind to mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) and increase its mRNA stability and translation, resulting in increased MKP-1 dephosphorylation activity and thereby inactivation of MAP kinases extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38.

Entrez Gene

Summary

This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10654261-10692417

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000250241	ENSP00000250241
ENST00000407004	ENSP00000384660
ENST00000449870	ENSP00000404121
ENST00000589998	ENSP00000465219
ENST00000593061	ENSP00000466724
ENST00000585835	ENSP00000467950
ENST00000589600	ENSP00000468134
ENST00000589052	ENSP00000468092
ENST00000587840	ENSP00000467704
ENST00000588657	ENSP00000468181
ENST00000587928
ENST00000590261	ENSP00000468156
ENST00000589283	ENSP00000466396
ENST00000587941	ENSP00000464974
ENST00000591649
ENST00000587505	ENSP00000466991
ENST00000589485	ENSP00000467372
ENST00000590009	ENSP00000465654
ENST00000592763	ENSP00000465515
ENST00000589173
ENST00000589416	ENSP00000465831
ENST00000593199	ENSP00000468323
ENST00000586544
ENST00000590869	ENSP00000466235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 334 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	334 [view]
Protein-Protein	317 [view]
Protein-DNA	2 [view]
Protein-RNA	15 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000279	M phase
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0017148	negative regulation of translation
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051607	defense response to virus

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032178

View Gene Order

ENSBTAG00000040076

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.465885

RefSeq

NM_001137673 NM_004516 NM_012218 NM_017620 NM_153464 XM_005259895

HUGO

OMIM

CCDS

CCDS12246 CCDS12247 CCDS45965 CCDS45966 CCDS45967

HPRD

04420

IMGT

EMBL

GenPept

RNA Seq Atlas