InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PER1

Summary

InnateDB Gene

IDBG-27996.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PER1

Gene Name

period homolog 1 (Drosophila)

Synonyms

hPER; PER; RIGUI

Species

Homo sapiens

Ensembl Gene

ENSG00000179094

Encoded Proteins

IDBP-27998

period homolog 1 (Drosophila)

IDBP-28000

period homolog 1 (Drosophila)

IDBP-761897

IDBP-759771

IDBP-763187

IDBP-758717

IDBP-763112

IDBP-758268

IDBP-760281

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jul 2008]
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:8140472-8156506

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000354903	ENSP00000346979
ENST00000317276	ENSP00000314420
ENST00000582719	ENSP00000463054
ENST00000578089
ENST00000585284
ENST00000577424
ENST00000579098
ENST00000585095
ENST00000578223
ENST00000577253	ENSP00000462546
ENST00000583677
ENST00000584202	ENSP00000463661
ENST00000579065
ENST00000581395	ENSP00000464696
ENST00000583559	ENSP00000463369
ENST00000581082	ENSP00000462064
ENST00000579203
ENST00000581703	ENSP00000463385
ENST00000578950

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	24 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000989	transcription factor binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019900	kinase binding
GO:0031490	chromatin DNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002028	regulation of sodium ion transport
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007623	circadian rhythm
GO:0009416	response to light stimulus
GO:0009649	entrainment of circadian clock
GO:0010608	posttranscriptional regulation of gene expression
GO:0032922	circadian regulation of gene expression
GO:0042634	regulation of hair cycle
GO:0042752	regulation of circadian rhythm
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043153	entrainment of circadian clock by photoperiod
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046329	negative regulation of JNK cascade
GO:0070932	histone H3 deacetylation
GO:0097167	circadian regulation of translation
GO:1900015	regulation of cytokine production involved in inflammatory response
GO:1900744	regulation of p38MAPK cascade
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020893

View Gene Order

ENSBTAG00000003889

Not yet available

Pathways

NETPATH

REACTOME

REACT_111118

BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway

REACT_24941

Circadian Clock pathway

KEGG

hsa04710

Circadian rhythm pathway

INOH

PID NCI

circadianpathway

Circadian rhythm pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.445534

RefSeq

NM_002616 XM_005256689

HUGO

OMIM

CCDS

CCDS11131

HPRD

03774

IMGT

EMBL

GenPept

RNA Seq Atlas