Version 5.4
Homo sapiens Gene: DLX5
Summary
InnateDB Gene IDBG-28081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLX5
Gene Name distal-less homeobox 5
Synonyms SHFM1D
Species Homo sapiens
Ensembl Gene ENSG00000105880
Encoded Proteins
IDBP-28083
distal-less homeobox 5
IDBP-810205
distal-less homeobox 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:97020392-97025097
Strand Reverse strand
Band q21.3
Transcripts
ENST00000222598 ENSP00000222598
ENST00000493764
ENST00000486603 ENSP00000475008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0071837 HMG box domain binding
Biological Process
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001958 endochondral ossification
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0008283 cell proliferation
GO:0030326 embryonic limb morphogenesis
GO:0030509 BMP signaling pathway
GO:0030855 epithelial cell differentiation
GO:0042472 inner ear morphogenesis
GO:0043583 ear development
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060021 palate development
GO:0060166 olfactory pit development
GO:0060322 head development
GO:0060325 face morphogenesis
GO:0060349 bone morphogenesis
GO:0071773 cellular response to BMP stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029755
View Gene Order
ENSBTAG00000018645
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL B7Z4P3
UniProt Splice Variant
Entrez Gene 1749
UniGene
RefSeq NM_005221 XM_005250185
HUGO HGNC:2918
OMIM 600028
CCDS CCDS5647
HPRD
IMGT
EMBL AC004774 AK297614
GenPept BAH12629
RNA Seq Atlas 1749

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca