InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FANCG

Summary

InnateDB Gene

IDBG-281538.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FANCG

Gene Name

Fanconi anemia, complementation group G

Synonyms

FAG; XRCC9

Species

Homo sapiens

Ensembl Gene

ENSG00000221829

Encoded Proteins

IDBP-61627

Fanconi anemia, complementation group G

IDBP-368092

Fanconi anemia, complementation group G

IDBP-368100

Fanconi anemia, complementation group G

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:35073835-35080016

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000378643	ENSP00000367910
ENST00000425676	ENSP00000412793
ENST00000448890	ENSP00000409607
ENST00000476212
ENST00000481254
ENST00000474894
ENST00000461149
ENST00000462124

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	64 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000160	phosphorelay signal transduction system
GO:0001541	ovarian follicle development
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007005	mitochondrion organization
GO:0007286	spermatid development
GO:0009314	response to radiation

Cellular Component

GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0043240	Fanconi anaemia nuclear complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028453

View Gene Order

ENSBTAG00000015005

Not yet available

Pathways

NETPATH

REACTOME

REACT_18410

Fanconi Anemia pathway pathway

REACT_216

DNA Repair pathway

KEGG

INOH

PID NCI

fanconi_pathway

Fanconi anemia pathway

bard1pathway

BARD1 signaling events

Cross-References

SwissProt

TrEMBL

C9JSE3

UniProt Splice Variant

Entrez Gene

2189

UniGene

Hs.591084

RefSeq

NM_004629

HUGO

HGNC:3588

OMIM

602956

CCDS

CCDS6574

HPRD

04262

IMGT

EMBL

AL353795

GenPept

RNA Seq Atlas

2189