Version 5.4
Homo sapiens Gene: PSG7
Summary
InnateDB Gene IDBG-281678.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSG7
Gene Name pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
Synonyms PSBG-7; PSG1; PSGGA
Species Homo sapiens
Ensembl Gene ENSG00000221878
Encoded Proteins
IDBP-477316
pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
IDBP-765311
IDBP-809828
pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
IDBP-809835
pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
IDBP-809836
pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The reference genome contains a nonsense mutation that disrupts the coding sequence, suggesting that this gene may be evolving into a pseudogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:42906822-43082671
Strand Reverse strand
Band q13.31
Transcripts
ENST00000406070 ENSP00000421986
ENST00000446844 ENSP00000470856
ENST00000471557
ENST00000599226
ENST00000599620
ENST00000623675 ENSP00000485117
ENST00000618424 ENSP00000478484
ENST00000617049 ENSP00000480429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5676
UniGene
RefSeq NM_001206650 NM_001290042 NM_002783
HUGO HGNC:9524
OMIM 176396
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 5676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca