Version 5.4
Homo sapiens Gene: THOC1
Summary
InnateDB Gene IDBG-282.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THOC1
Gene Name THO complex 1
Synonyms HPR1; P84; P84N5
Species Homo sapiens
Ensembl Gene ENSG00000079134
Encoded Proteins
IDBP-284
THO complex 1
IDBP-809385
THO complex 1
IDBP-727425
IDBP-726557
IDBP-809383
THO complex 1
IDBP-727358
IDBP-809387
THO complex 1
IDBP-809388
THO complex 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:214520-268050
Strand Reverse strand
Band p11.32
Transcripts
ENST00000261600 ENSP00000261600
ENST00000578224
ENST00000584642 ENSP00000473499
ENST00000578529
ENST00000583228
ENST00000584470
ENST00000581269 ENSP00000463965
ENST00000582313
ENST00000581116 ENSP00000461943
ENST00000580544
ENST00000579232
ENST00000585307
ENST00000579891 ENSP00000473276
ENST00000581576
ENST00000580870
ENST00000580038 ENSP00000462757
ENST00000577429
ENST00000577552
ENST00000616322 ENSP00000480460
ENST00000621904 ENSP00000481599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
Experimentally validated
Total 64 [view]
Protein-Protein 60 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008380 RNA splicing
GO:0031297 replication fork processing
GO:0032784 regulation of DNA-templated transcription, elongation
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0046784 intronless viral mRNA export from host nucleus
GO:0048297 negative regulation of isotype switching to IgA isotypes
GO:2000002 negative regulation of DNA damage checkpoint
Cellular Component
GO:0000346 transcription export complex
GO:0000347 THO complex
GO:0000445 THO complex part of transcription export complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0045171 intercellular bridge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024287
View Gene Order
ENSBTAG00000019215
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.712543
RefSeq NM_005131
HUGO
OMIM
CCDS CCDS45820
HPRD 09498
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca