Version 5.4
Homo sapiens Gene: ASNS
Summary
InnateDB Gene IDBG-28257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASNS
Gene Name asparagine synthetase (glutamine-hydrolyzing)
Synonyms ASNSD; TS11
Species Homo sapiens
Ensembl Gene ENSG00000070669
Encoded Proteins
IDBP-28259
asparagine synthetase (glutamine-hydrolyzing)
IDBP-241855
asparagine synthetase (glutamine-hydrolyzing)
IDBP-241857
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382496
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382498
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382500
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382502
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382503
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382504
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382505
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382509
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382511
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382512
asparagine synthetase (glutamine-hydrolyzing)
IDBP-382513
asparagine synthetase (glutamine-hydrolyzing)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:97852118-97872542
Strand Reverse strand
Band q21.3
Transcripts
ENST00000175506 ENSP00000175506
ENST00000394309 ENSP00000377846
ENST00000394308 ENSP00000377845
ENST00000437628 ENSP00000414379
ENST00000454046 ENSP00000401651
ENST00000422745 ENSP00000414901
ENST00000455086 ENSP00000408472
ENST00000444334 ENSP00000406994
ENST00000442734 ENSP00000400422
ENST00000437657 ENSP00000394242
ENST00000448127 ENSP00000402350
ENST00000453600 ENSP00000408797
ENST00000451771 ENSP00000397802
ENST00000414884 ENSP00000413797
ENST00000487714
ENST00000462436
ENST00000495255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
Experimentally validated
Total 51 [view]
Protein-Protein 44 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
GO:0005524 ATP binding
GO:0042803 protein homodimerization activity
GO:0048037 cofactor binding
Biological Process
GO:0001889 liver development
GO:0006520 cellular amino acid metabolic process
GO:0006529 asparagine biosynthetic process
GO:0006541 glutamine metabolic process
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0008152 metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009416 response to light stimulus
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031427 response to methotrexate
GO:0031667 response to nutrient levels
GO:0032354 response to follicle-stimulating hormone
GO:0032870 cellular response to hormone stimulus
GO:0034641 cellular nitrogen compound metabolic process
GO:0042149 cellular response to glucose starvation
GO:0043066 negative regulation of apoptotic process
GO:0043200 response to amino acid
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0045931 positive regulation of mitotic cell cycle
GO:0070981 L-asparagine biosynthetic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029752
View Gene Order
ENSBTAG00000003222
Not yet available
Pathways
NETPATH
REACTOME
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Alanine Aspartate Asparagine metabolism pathway
PID NCI
Cross-References
SwissProt P08243
TrEMBL C9J057 C9J605 C9JLA3 C9JM09 C9JT45
UniProt Splice Variant
Entrez Gene 440
UniGene Hs.489207
RefSeq NM_001673 NM_001178075 NM_001178076 NM_001178077 NM_133436 NM_183356
HUGO HGNC:753
OMIM 108370
CCDS CCDS5652 CCDS55131 CCDS55132
HPRD 00153
IMGT
EMBL AC005326 AC079781 AK302189 AK316224 BC008723 BC014621 BT007113 CH236949 CH471091 L35936 L35937 L35938 L35939 L35940 L35941 L35942 L35943 L35944 L35945 L35946 M15798 M27054 M27396
GenPept AAA36781 AAA51789 AAA52756 AAA63266 AAH08723 AAH14621 AAP35777 AAQ96856 BAG63553 BAH14595 EAL24115 EAW76723 EAW76730 EAW76731 EAW76732 EAW76733
RNA Seq Atlas 440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca