InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AURKB

Summary

InnateDB Gene

IDBG-28278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AURKB

Gene Name

aurora kinase B

Synonyms

AIK2; AIM-1; AIM1; ARK2; AurB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK12; STK5

Species

Homo sapiens

Ensembl Gene

ENSG00000178999

Encoded Proteins

IDBP-28282

aurora kinase B

IDBP-599743

aurora kinase B

IDBP-757975

IDBP-763205

IDBP-764877

IDBP-760697

IDBP-757863

IDBP-764257

IDBP-759428

IDBP-757806

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:8204733-8210600

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000316199	ENSP00000313950
ENST00000534871	ENSP00000443869
ENST00000584972	ENSP00000462858
ENST00000585124	ENSP00000463999
ENST00000580998	ENSP00000461981
ENST00000583915	ENSP00000462027
ENST00000582368	ENSP00000464031
ENST00000584561
ENST00000580390
ENST00000578753
ENST00000583124
ENST00000578549	ENSP00000462207
ENST00000581511	ENSP00000462930
ENST00000577833	ENSP00000463636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 203 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	203 [view]
Protein-Protein	195 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035174	histone serine kinase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0002903	negative regulation of B cell apoptotic process
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0007568	aging
GO:0008283	cell proliferation
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0009838	abscission
GO:0016570	histone modification
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031565	cytokinesis checkpoint
GO:0031577	spindle checkpoint
GO:0032091	negative regulation of protein binding
GO:0032466	negative regulation of cytokinesis
GO:0032467	positive regulation of cytokinesis
GO:0034501	protein localization to kinetochore
GO:0034644	cellular response to UV
GO:0036089	cleavage furrow formation
GO:0043146	spindle stabilization
GO:0043988	histone H3-S28 phosphorylation
GO:0046777	protein autophosphorylation
GO:0051256	spindle midzone assembly involved in mitosis
GO:0051983	regulation of chromosome segregation

Cellular Component

GO:0000779	condensed chromosome, centromeric region
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0005819	spindle
GO:0005829	cytosol
GO:0010369	chromocenter
GO:0030496	midbody
GO:0032133	chromosome passenger complex
GO:0045171	intercellular bridge