Version 5.4
Homo sapiens Gene: MMP14
Summary
InnateDB Gene IDBG-2848.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMP14
Gene Name matrix metallopeptidase 14 (membrane-inserted)
Synonyms MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS
Species Homo sapiens
Ensembl Gene ENSG00000157227
Encoded Proteins
IDBP-2850
matrix metallopeptidase 14 (membrane-inserted)
IDBP-601197
matrix metallopeptidase 14 (membrane-inserted)
IDBP-599184
matrix metallopeptidase 14 (membrane-inserted)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:22836557-22849027
Strand Forward strand
Band q11.2
Transcripts
ENST00000311852 ENSP00000308208
ENST00000547074
ENST00000548162
ENST00000547279 ENSP00000450323
ENST00000548761 ENSP00000446989
ENST00000547596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016504 peptidase activator activity
Biological Process
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001666 response to hypoxia
GO:0001935 endothelial cell proliferation
GO:0001958 endochondral ossification
GO:0006355 regulation of transcription, DNA-templated
GO:0006508 proteolysis
GO:0006979 response to oxidative stress
GO:0008584 male gonad development
GO:0009612 response to mechanical stimulus
GO:0009725 response to hormone
GO:0010952 positive regulation of peptidase activity
GO:0014070 response to organic cyclic compound
GO:0016477 cell migration
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030307 positive regulation of cell growth
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030574 collagen catabolic process
GO:0031638 zymogen activation
GO:0035988 chondrocyte proliferation
GO:0043615 astrocyte cell migration
GO:0043627 response to estrogen
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048771 tissue remodeling
GO:0051895 negative regulation of focal adhesion assembly
GO:0060348 bone development
GO:0097094 craniofacial suture morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0031012 extracellular matrix
GO:0042470 melanosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000957
View Gene Order
ENSBTAG00000014824
Not yet available
Pathways
NETPATH
NetPath_22
Leptin pathway
REACTOME
REACT_118682
Activation of Matrix Metalloproteinases pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
hsa04912
GnRH signaling pathway pathway
INOH
PID NCI
hif2pathway
HIF-2-alpha transcription factor network
Cross-References
SwissProt P50281
TrEMBL F8VP90 F8W1B7
UniProt Splice Variant
Entrez Gene 4323
UniGene Hs.2399
RefSeq NM_004995
HUGO HGNC:7160
OMIM 600754
CCDS CCDS9577
HPRD
IMGT
EMBL AK291325 AL135998 AY795074 BC064803 D26512 U41078 X83535 X90925 Z48481
GenPept AAA83770 AAH64803 AAV40837 BAA05519 BAF84014 CAA58519 CAA62432 CAA88372
RNA Seq Atlas 4323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca