Version 5.4
Homo sapiens Gene: ARHGEF15
Summary
InnateDB Gene IDBG-28708.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF15
Gene Name Rho guanine nucleotide exchange factor (GEF) 15
Synonyms ARGEF15; E5; Ephexin5; Vsm-RhoGEF
Species Homo sapiens
Ensembl Gene ENSG00000198844
Encoded Proteins
IDBP-28712
Rho guanine nucleotide exchange factor (GEF) 15
IDBP-367650
Rho guanine nucleotide exchange factor (GEF) 15
IDBP-762467
IDBP-762553
IDBP-759716
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:8310241-8322516
Strand Forward strand
Band p13.1
Transcripts
ENST00000361926 ENSP00000355026
ENST00000421050 ENSP00000412505
ENST00000455564
ENST00000583529 ENSP00000462796
ENST00000581809 ENSP00000463875
ENST00000582060
ENST00000579439 ENSP00000464540
ENST00000578286
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0050790 regulation of catalytic activity
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:2000297 negative regulation of synapse maturation
Cellular Component
GO:0030425 dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052921
View Gene Order
ENSBTAG00000020688
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
epha_fwdpathway
EPHA forward signaling
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443109
RefSeq NM_025014 NM_173728 XM_005256537
HUGO
OMIM
CCDS CCDS11139
HPRD 10535
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca