InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMURF1

Summary

InnateDB Gene

IDBG-28871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMURF1

Gene Name

SMAD specific E3 ubiquitin protein ligase 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000198742

Encoded Proteins

IDBP-28873

SMAD specific E3 ubiquitin protein ligase 1

IDBP-28875

SMAD specific E3 ubiquitin protein ligase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:99027438-99144100

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000361125	ENSP00000354621
ENST00000361368	ENSP00000355326
ENST00000480055
ENST00000472627

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 441 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	441 [view]
Protein-Protein	433 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	8 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0048185	activin binding
GO:0070411	I-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006611	protein export from nucleus
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007398	ectoderm development
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation
GO:0030279	negative regulation of ossification
GO:0030509	BMP signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0032801	receptor catabolic process
GO:0034394	protein localization to cell surface
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome