Version 5.4
Homo sapiens Gene: HMGCR
Summary
InnateDB Gene IDBG-28893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGCR
Gene Name 3-hydroxy-3-methylglutaryl-CoA reductase
Synonyms LDLCQ3
Species Homo sapiens
Ensembl Gene ENSG00000113161
Encoded Proteins
IDBP-28897
3-hydroxy-3-methylglutaryl-CoA reductase
IDBP-28899
3-hydroxy-3-methylglutaryl-CoA reductase
IDBP-390214
3-hydroxy-3-methylglutaryl-CoA reductase
IDBP-475307
3-hydroxy-3-methylglutaryl-CoA reductase
IDBP-479977
3-hydroxy-3-methylglutaryl-CoA reductase
IDBP-476067
3-hydroxy-3-methylglutaryl-CoA reductase
IDBP-477842
3-hydroxy-3-methylglutaryl-CoA reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:75336329-75362104
Strand Forward strand
Band q13.3
Transcripts
ENST00000287936 ENSP00000287936
ENST00000343975 ENSP00000340816
ENST00000442032 ENSP00000409100
ENST00000511206 ENSP00000426745
ENST00000509431
ENST00000507942 ENSP00000427340
ENST00000504466
ENST00000515776
ENST00000508070
ENST00000514315
ENST00000509085 ENSP00000421378
ENST00000511986 ENSP00000420871
ENST00000512053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515 protein binding
GO:0008158 hedgehog receptor activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042282 hydroxymethylglutaryl-CoA reductase activity
GO:0042803 protein homodimerization activity
GO:0050661 NADP binding
GO:0050662 coenzyme binding
GO:0070402 NADPH binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006743 ubiquinone metabolic process
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell proliferation
GO:0008299 isoprenoid biosynthetic process
GO:0008542 visual learning
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0015936 coenzyme A metabolic process
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0043066 negative regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045445 myoblast differentiation
GO:0045471 response to ethanol
GO:0045908 negative regulation of vasodilation
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051262 protein tetramerization
GO:0055114 oxidation-reduction process
GO:0061045 negative regulation of wound healing
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021670
View Gene Order
ENSBTAG00000007840
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
hsa04976
Bile secretion pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.628096 Hs.643495
RefSeq NM_000859 NM_001130996
HUGO
OMIM
CCDS CCDS4027 CCDS47234
HPRD 00836
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca