Version 5.4
Homo sapiens Gene: RAPGEF3
Summary
InnateDB Gene IDBG-28934.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAPGEF3
Gene Name Rap guanine nucleotide exchange factor (GEF) 3
Synonyms bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Species Homo sapiens
Ensembl Gene ENSG00000079337
Encoded Proteins
IDBP-28938
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-239673
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-293542
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-373339
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-588988
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-586706
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-592997
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-602218
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-584356
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-585933
Rap guanine nucleotide exchange factor (GEF) 3
IDBP-587954
Rap guanine nucleotide exchange factor (GEF) 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:47734672-47771040
Strand Reverse strand
Band q13.11
Transcripts
ENST00000389212 ENSP00000373864
ENST00000395360
ENST00000395358 ENSP00000378764
ENST00000405493 ENSP00000384521
ENST00000449771 ENSP00000395708
ENST00000479866
ENST00000482843
ENST00000488250
ENST00000490387
ENST00000473777
ENST00000476259
ENST00000495465 ENSP00000449818
ENST00000494764
ENST00000466322 ENSP00000446731
ENST00000495953 ENSP00000448804
ENST00000547856 ENSP00000449905
ENST00000549151 ENSP00000448619
ENST00000548919 ENSP00000448480
ENST00000548434 ENSP00000447691
ENST00000549347
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0017034 Rap guanyl-nucleotide exchange factor activity
GO:0030552 cAMP binding
Biological Process
GO:0001525 angiogenesis
GO:0006112 energy reserve metabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0019933 cAMP-mediated signaling
GO:0030168 platelet activation
GO:0030822 positive regulation of cAMP catabolic process
GO:0032486 Rap protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0044281 small molecule metabolic process
GO:0045766 positive regulation of angiogenesis
GO:0045859 regulation of protein kinase activity
GO:0050796 regulation of insulin secretion
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051496 positive regulation of stress fiber assembly
GO:0061028 establishment of endothelial barrier
GO:0071320 cellular response to cAMP
GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022469
View Gene Order
ENSBTAG00000006828
Not yet available
Pathways
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa04720
Long-term potentiation pathway
hsa04670
Leukocyte transendothelial migration pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.8578
RefSeq NM_001098531 NM_001098532 NM_006105 XM_005268569 XM_005268570 XM_005268571
HUGO
OMIM
CCDS CCDS31784 CCDS41775
HPRD 06928
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca