InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDIA6

Summary

InnateDB Gene

IDBG-29164.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDIA6

Gene Name

protein disulfide isomerase family A, member 6

Synonyms

ERP5; P5; TXNDC7

Species

Homo sapiens

Ensembl Gene

ENSG00000143870

Encoded Proteins

IDBP-29166

protein disulfide isomerase family A, member 6

IDBP-29168

protein disulfide isomerase family A, member 6

IDBP-292773

protein disulfide isomerase family A, member 6

IDBP-292774

protein disulfide isomerase family A, member 6

IDBP-363725

protein disulfide isomerase family A, member 6

IDBP-588082

protein disulfide isomerase family A, member 6

IDBP-811907

protein disulfide isomerase family A, member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:10783391-10837977

Strand

Reverse strand

Band

p25.1

Transcripts

ENST00000381611	ENSP00000371024
ENST00000272227	ENSP00000272227
ENST00000404371	ENSP00000385385
ENST00000404824	ENSP00000384459
ENST00000458536	ENSP00000389558
ENST00000489662
ENST00000540494	ENSP00000438778
ENST00000617249	ENSP00000481892

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	71 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity

Biological Process

GO:0006457	protein folding
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034976	response to endoplasmic reticulum stress
GO:0043277	apoptotic cell clearance
GO:0044267	cellular protein metabolic process
GO:0045454	cell redox homeostasis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005886	plasma membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020571

View Gene Order

ENSBTAG00000001928

Not yet available

Pathways

NETPATH

REACTOME

REACT_18273

XBP1(S) activates chaperone genes pathway

REACT_18368

IRE1alpha activates chaperones pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

Q15084

TrEMBL

UniProt Splice Variant

Entrez Gene

10130

UniGene

Hs.212102 Hs.739130 Hs.739169 Hs.739363

RefSeq

NM_001282704 NM_001282705 NM_001282706 NM_001282707 NM_005742 XM_005246145

HUGO

HGNC:30168

OMIM

611099

CCDS

CCDS62854 CCDS1675 CCDS62852 CCDS62853 CCDS62855

HPRD

07504

IMGT

EMBL

AC092687 AK127433 AK131234 AK289428 AK294347 AK297547 BC001312 CH471053 D49489 U79278

GenPept

AAB50217 AAH01312 AAY24070 BAA08450 BAC86977 BAF82117 BAG54757 BAH11740 BAH12614 EAX00950

RNA Seq Atlas

10130