Homo sapiens Gene: VPS35
Summary
InnateDB Gene IDBG-29257.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol VPS35
Gene Name vacuolar protein sorting 35 homolog (S. cerevisiae)
Synonyms MEM3; PARK17;
Species Homo sapiens
Ensembl Gene ENSG00000069329
Encoded Proteins
vacuolar protein sorting 35 homolog (S. cerevisiae)
Protein Structure
Entrez Gene
Summary This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:46690054-46723430
Strand Reverse strand
Band q11.2
Transcripts
ENST00000299138 ENSP00000299138
ENST00000568784 ENSP00000456274
ENST00000561713 ENSP00000461423
ENST00000569950
ENST00000568642
ENST00000568191
ENST00000568612 ENSP00000461469
ENST00000565228
ENST00000563884
ENST00000562420
ENST00000563984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 76 [view]
Protein-Protein 74 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0008219 cell death
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005768 endosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q96QK1
TrEMBL H3BRJ7 I3L4P4 I3L4S0
UniProt Splice Variant
Entrez Gene 55737
UniGene Hs.595143 Hs.717753
RefSeq NM_018206
HUGO 13487
OMIM 601501
CCDS CCDS10721
HPRD 06085
IMGT
EMBL AC007225 AC012186 AF175265 AF183418 AF186382 AF191298 AK000395 AK001614 AK023650 AL136888 AL512769 AY007112 BC002414 BC010362 BC093036
GenPept AAF02778 AAF89953 AAG01989 AAG09687 AAG40619 AAH02414 AAH10362 AAH93036 BAA91137 BAA91790 BAB14626 CAB66822 CAC21686
ImmGen VPS35 (murine)
RNA Seq Atlas 55737